Antisense Technology
Egr-1 antisense molecules interfere with fear conditioning in rats
Published in Gene Therapy Weekly, December 23rd, 2004
According to published research from the United States, "studies of gene expression following fear conditioning have demonstrated that the inducible transcription factor, egr-1, is increased in the lateral nucleus of the amygdala shortly following fear conditioning. These studies suggest that egr-l and its protein product Egr-I in the amygdala are important for learning and memory of fear."
"To directly test this hypothesis, an egr-l antisense oligodeoxynucleotide (antisense-ODN) was injected bilaterally into the amygdala prior to contextual fear conditioning," wrote S. Malkani and...
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Source: Gene Therapy Weekly (2004-12-23)
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