Gene Therapy Weekly

Glycosylation - Glycosylation in follistatin analyzed, site specificity revealed

Gynecology - Simultaneous blockade of Bcl-2 and DNA repair staunches ovarian cancer growth

Hematology - A Jak2-based cell growth switch selects genetically modified erythroid cells

Hepatology - Liver site-specific gene transfer generates protein in murine models

Herceptin Therapy - Study: Efficacy of Herceptin therapy is influenced by several factors

Intestinal Cancer - Epiregulin deficiency does not alter intestinal cancer susceptibility

Kaposi Sarcoma-Associated Herpesvirus - Defective KSHV is present in KS tumors and primary effusion lymphoma cells

Licensing Agreement - Dyax grants use of its antibody phage display libraries for antibody development

Liver Disease - Gene transfer procedures may correct inborn liver metabolism disorders

Miscarriage - Gene defect may be a cause of miscarriage

Multiple Sclorosis - Relapsing multiple sclorosis treatment approved by U.S. FDA

Neurotoxicity - Sonic hedgehog and Gli-1 protect nigrostriatal neurons from neurotoxic insult

Non-Viral Vectors - Pulse polarity and direction influence electroporation-based gene transfer

Oncology - Pharma companies announce oncology therapeutics research milestone

Ophthalmology - Antisense oligonucleotides focus on the control of ocular angiogenesis

Organ Transplantation - Riverdale woman shares kidney with baby sitter's daughter

Osteoporosis - Pharma company expands scope of new drug application PREOS

Patents - U.S. Patent covering protein formulations of engineered zinc fingers granted

Personnel - Biotech company names vice president of sales

Personnel - Biotechnology company announces new board member

Personnel - H. Thomas Watkins appointed CEO

Personnel - Paul N. Lucas appointed chairman of genetics-focused biosciences company board

Protein Regulation - Electrical signals stimulate proteins that heal orthopedic injury or arthritis

Proteomics - Pharma company announces results of human lactoferrin study

Pulmonary Medicine - Airway epithelium receptors improve adenovirus-based gene transfer

Recombinant Research - The recombinant protein fibstatin is a potent suppressor of angiogenesis

Skin Cancer - p53 point mutation at Ser389 increases sensitivity to UV radiation

Stem Cell Research - Creating $3 billion stem cell agency no small feat

Stem Cell Research - Distinct cell "side population" has high drug efflux capacity in tumor cells

Stem Cell Research - Lentiviral vectors funnel genes into neural stem cells for therapeutic use

Stem Cell Research - Study data show hESC-derived oligodendrocytes remyelinate in vivo

Transfection - Electroporation-assisted gene transfer yields gene expression in murine muscles

Vaccine Development - Fused heat shock proteins do not guarantee the success of DNA vaccines

Vaccine Vector - Method for selecting retroviral-producing cells developed

Vector Development - Lipophosphoramides offer a safe alternative to viral gene vectors

Vector Production - Culture passage influences the titer of viral vectors cultivated on monolayers

Viral Vectors - Optimized inducible vectors improve transfection and transgene expression

Virology - Lentiviral transduction of cord SCs yields high-level beta-globin expression