Cancer Therapy
Blocked thymidine phosphorylase augments paclitaxel efficacy in prostate cancer
Published in Gene Therapy Weekly, December 30th, 2004
"Recently, survival benefit by chemotherapy using paclitaxel (PTX) and the induction of thymidine phosphorylase (TP) by PTX have been reported in several solid tumors. On the other hand, TP confers antiapoptotic effect on tumor cells through inhibition of caspase-8 activation in vitro. On the basis of these previous observations, we hypothesized that (a) TP can be induced after PTX treatment in human prostate cancer (PC) and (b) blockade of PTX-induced TP expression can enhance the apoptotic processes in human PC cells," scientists in Japan report.
"PTX was used to find...
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Source: Gene Therapy Weekly (2004-12-30)
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