Diagnostic Imaging
Vaccinia virus expressing SSTR2 permits noninvasive tumor imaging
Published in Gene Therapy Weekly, December 30th, 2004
"Oncolytic vaccinia viruses (VV) have demonstrated tumor specificity, high levels of transgene expression, and anti-tumor effects. The ability to visualize vector biodistribution noninvasively will be necessary as gene therapy vectors come to clinical trials, and the creation of a VV that can both treat tumors and permit noninvasive imaging after systemic delivery is therefore an exciting concept. To facilitate imaging, a VV expressing the human somatostatin receptor type 2 (SSTR2) was created," scientists in Canada report.
"Cells infected with the SSTR2-expressing VV or controls were...
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Source: Gene Therapy Weekly (2004-12-30)
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