Non-Viral Vectors
Pulse polarity and direction influence electroporation-based gene transfer
Published in Gene Therapy Weekly, December 30th, 2004
According to published research from France, "electropermeabilization is a nonviral method used to transfer genes into living cells. Up to now, the mechanism is still to be elucidated. Since cell permeabilization, a prerequired for gene transfection, is triggered by electric field, its characteristics should depend on its vectorial properties."
"The present investigation addresses the effect of pulse polarity and orientation on membrane permeabilization and gene delivery by electric pulses applied to cultured mammalian cells. This has been directly observed at the single-cell...
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Source: Gene Therapy Weekly (2004-12-30)
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