Skin Cancer
p53 point mutation at Ser389 increases sensitivity to UV radiation
Published in Gene Therapy Weekly, December 30th, 2004
"Phosphorylation is important for p53 protein stabilization and activation after DNA damage. Serine 389 of p53 is specifically phosphorylated after UV irradiation, whereas gamma radiation activates p53 through a different pathway.
"To study the in vivo significance of p53 phosphorylation at serine 389, we generated a physiological mouse model in which p53 phosphorylation at serine 389 is abolished by alanine substitution," scientists writing in the journal Molecular and Cellular Biology report.
"Homozygous mutant p53.S389A mice are viable and have an...
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Source: Gene Therapy Weekly (2004-12-30)
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