Ovarian Cancer

BRAF and KRAS mutations precede development of ovarian serous borderline tumors

Published in Gene Therapy Weekly, January 6th, 2005

BRAF and KRAS mutations precede the development of ovarian serous borderline tumors.

"Molecular genetic changes that are associated with the initiating stage of tumor development are important in tumorigenesis. Ovarian serous borderline tumors (SBTs), putative precursors of low-grade serous carcinomas, are among the few human neoplasms with a high frequency of activating mutations in BRAF and KPAS genes.

"However, it remains unclear as to how these mutations contribute to tumor progression. To address this issue, we compared the mutational status of BRAF and KFAS in both SBTs and the adjacent epithelium from cystadenomas, the presumed precursor of...

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Source: Gene Therapy Weekly (2005-01-06)

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