Peptides

CNS can initiate its own defense against reactive oxygen species, free radicals

Published in Gene Therapy Weekly, January 6th, 2005

New synthetic peptides can enhance gene expression of key antioxidant defense enzymes in vitro and in vivo.

According to recent research published in the journal Brain Research, "Neurodegenerative, cardiovascular, and age-related disorders have been attributed to the cellular damage caused by elevated production of reactive oxygen species (ROS) and free radicals (FRs). These cannot be adequately defended by existing levels of key antioxidant enzymes."

V.E. Shashoua and colleagues of the University of Massachusetts explained, "Two peptides, 8 and 14 amino acids long, were synthesized and found to up-regulate, at nanomolar concentrations,...

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Source: Gene Therapy Weekly (2005-01-06)

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