Oncogenesis
Silenced hdm2 prevents the growth of p53-dependent human breast cancer
Published in Gene Therapy Weekly, January 13th, 2005
"RNA interference technology is a powerful tool for silencing endogenous or exogenous genes in mammalian cells. Here our results showed that hdm2-siRNA silenced its target mRNA specifically and effectively in human breast cancer cells, reduced tumor cell proliferation, and induced apoptotic cell death," scientists writing in the journal Cancer Gene Therapy report.
"Other molecular features modified by hdm2-siRNA included decreased Bcl-2, nuclear factor-kappaB, survivin, Ras and Raf levels, elevated p53, p21, BRCA1, Bax, and caspase levels as well as altered expression of...
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Source: Gene Therapy Weekly (2005-01-13)
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