Malignant Mesothelioma
MM cells expressing Slug have increased resistance to chemotherapeutic agents
Published in Gene Therapy Weekly, January 27th, 2005
"Malignant mesothelioma (MM) is strongly resistant to conventional chemotherapy by unclear mechanisms. We and others have previously reported that cytokine- and growth factor-mediated signal transduction is involved in the growth and progression of MM.
"Here, we identified a pathway that involves stem cell factor (SCF)/c-Kit/Slug in mediating multidrug resistance of MM cells," investigators in Italy report.
"When we compared gene expression profiles between five MM cells and their multidrug-resistant (MM DX) sublines," A. Catalano...
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Source: Gene Therapy Weekly (2005-01-27)
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