RNA Research
RNA polymerase II-dependent promoter derivatives expand the potential of siRNA
Published in Gene Therapy Weekly, January 27th, 2005
"RNA interference has emerged as a powerful technology for down-regulation of specific genes in cells and animals. We have pioneered macrolide- and tetracycline-adjustable short interfering RNA (siRNA) expression for conditional target gene translation fine-tuning in mammalian/human cell lines based on modified RNA polymerase II promoters," scientists writing in the journal Biotechnology and Bioengineering report.
"Established macrolide- and tetracycline-dependent transactivators/trans-silencers bound and activated modified target promoters tailored for optimal...
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Source: Gene Therapy Weekly (2005-01-27)
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