Bioengineering
Genetically modified progenitor cells augment therapeutic angiogenesis
Published in Gene Therapy Weekly, February 3rd, 2005
According to a study from South Korea, "previously we reported that inhibition of glycogen synthase kinase-3beta (GSK3beta), a key regulator in many intracellular signaling pathways, enhances the survival and migration of vascular endothelial cells. Here we investigated the effect of inhibition of GSK3beta activity on the angiogenic function of endothelial progenitor cell (EPC) and demonstrated a new therapeutic angiogenesis strategy using genetically modified EPC."
"As we previously reported, two biologically distinct types of EPC, spindle-shaped 'early EPC' and...
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Source: Gene Therapy Weekly (2005-02-03)
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