Bioengineering
Matrix-embedded marrow stromal cells provide long-term protein expression
Published in Gene Therapy Weekly, February 3rd, 2005
According to a study from Canada, "bone marrow stromal cells (MSCs) can be exploited therapeutically in transgenic cell therapy approaches. Our aim was to determine if gene-modified MSCs sequestered within a clinically approved, bovine type I collagen-based viscous bulking material could serve as a retrievable implant for systemic delivery of erythropoietin (Epo)."
"To test this hypothesis, we embedded Epo-secreting MSCs in viscous collagen (Contigen) and determined the pharmacological effect following implantation in normal mice," said N. Eliopoulos and colleagues, McGill...
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Source: Gene Therapy Weekly (2005-02-03)
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