Published in Gene Therapy Weekly, February 3rd, 2005
"Targeting unique mRNA molecules using antisense approaches, based on sequence specificity of double-stranded nucleic acid interactions should, in theory, allow for design of drugs with high specificity for intended targets. Antisense-induced degradation or inhibition of translation of a target mRNA is potentially capable of inhibiting the expression of any target protein. In fact, a large number of proteins of widely varied character have been successfully down-regulated using an assortment of antisense-based approaches," researchers in Canada report.
"The most prevalent...
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