Myocardial Infarction
Insulin-like growth factor-1 fosters muscle cell survival after implantation
Published in Gene Therapy Weekly, February 10th, 2005
"The functional benefit of cell transplantation after a myocardial infarction is diminished by early cell losses. Insulin-like growth factor 1 (IGF-1) enhances cell proliferation and survival. We hypothesized that IGF-1-transfected smooth muscle cells (SMCs) would enhance cell survival and improve engraftment after cell transplantation," researchers in Canada report.
"The IGF-1 gene was transfected into male SMCs and compared with SMCs transfected with a plasmid vector (vector control) and nontransfected SMCs (cell control). IGF-1 mRNA (n=10/group) and protein levels...
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Source: Gene Therapy Weekly (2005-02-10)
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