Oncology
The ectodermal neural cortex 1 gene is upregulated in hairy cell leukemia
Published in Gene Therapy Weekly, February 10th, 2005
According to a study from Sweden, "karyotypical alteration of chromosome 5 and in particular band 5q13 is a frequent finding in hairy cell leukemia (HCL). We have previously identified a number of candidate genes localized in close proximity to a constitutional inv(5)(p13.1q13.3) breakpoint in one HCL patient. These included beta-hexosaminodase HEXB, frequently mutated in the lysosomal storage disorder Sandhoff disease."
"We now report that the 5q13.3 breakpoint disrupts a novel evolutionary conserved alternative isoform of HEXB. This isoform directly overlaps, in a...
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Source: Gene Therapy Weekly (2005-02-10)
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