Drug Resistance

P-glycoprotein is a target for beating refractory autoimmune diseases

Published in Gene Therapy Weekly, February 17th, 2005

P-glycoprotein is a target for beating refractory autoimmune diseases.

"P-glycoprotein, encoded by the multidrug resistance (MDR)-1 gene, expels various drugs from cells resulting in drug resistance. However, its functional relevance to lymphocytes and the regulatory mechanism remain unclear. Although MDR-1 is known to be induced by various cytotoxic stimuli, it is poorly understood whether the activation stimuli such as cytokines induce MDR-1 transcription," researchers in Japan report.

"We investigated the transcriptional regulation of MDR-1 in lymphocytes by activation stimuli, particularly by interleukin (IL)-2," said S. Tsujimura and colleagues,...

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Source: Gene Therapy Weekly (2005-02-17)

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