Restenosis
Dominant negative protein receptor mitigates arterial hyperplasia
Published in Gene Therapy Weekly, February 17th, 2005
According to a study from Korea, "blocking of the insulin-like growth factor 1 (IGF-1) signaling pathway targeting the IGF-1 receptor (IGF-1R) provides a potential treatment strategy for restenosis. In this study, we have examined the effects of a dominant negative IGF-1R (IGF-1Rt) on primary rat VSMCs in vitro and on injured rat carotid artery in vivo."
"Ad/IGF-1Rt infection inhibited VSMC migration and proliferation, and it also induced apoptosis by inhibiting phosphorylation of Akt and phosphorylation of ERK1/2," said H.J. Lim and colleagues, Yonsei University College of Medicine,...
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Source: Gene Therapy Weekly (2005-02-17)
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