Apoptosis
Rho/rhotekin-mediated NF-kappa B activation confers resistance to apoptosis
Published in Gene Therapy Weekly, February 24th, 2005
According to recent research published in the journal Oncogene, "Rhotekin (RTKN), the gene coding for the Rho effector, RTKN, was shown to be overexpressed in human gastric cancer (GC).
"In this study, we further showed that RTKN is expressed at a low level in normal cells and is overexpressed in many cancer-derived cell lines. The function of RTKN as an effector protein in Rho GTPase-mediated pathways regulating apoptosis was investigated."
"By transfection and expression of RTKN in cells that expressed endogenous RTKN at a low basal level,"...
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Source: Gene Therapy Weekly (2005-02-24)
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