Published in Gene Therapy Weekly, February 24th, 2005
According to published research from the Netherlands, "favorable pharmacokinetics of the prodrug are essential for successful herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) suicide gene therapy. [18F]FHPG positron emission tomography (PET) might be a suitable technique to assess the pharmacokinetics of the prodrug GCV noninvasively, provided that [18F]FHPG mimics the behavior of GCV."
"Since membrane transport is an important aspect of the pharmacokinetics of the prodrug, we investigated the cellular uptake mechanism of [18F]FHPG in an...
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