Gene Therapy Weekly

Anthrax Risk Factors - Host ARAP3 production makes cells vulnerable to anthrax toxin

Brain Cancer - The attenuated adenovirus ONYX-015 fights glioma proliferation

Cancer Therapy - Fusion transgene elicits a robust immunological response to tumor cells

Gene Transfer - Gene transduction corrects cells from patients with Wiskott-Aldrich syndrome

Genetic Engineering - Genetically modified cytolytic T cells recognize and kill glioblastoma

Acute Myeloid Leukemia - XPD genetic variation predicts treatment outcome and AML risk after chemotherapy

Allergy and Immunology - Interleukin-10 gene transfer battles harmful Th1-type responses

Batten Disease - Company announces U.S. FDA interchange on proposed clinical trials of stem cells

Biomedical Engineering - University of Arkansas for Medical Sciences adopts tissue management system

Breast Cancer - Breast carcinoma cell line is resistant to DNA-damaging drugs

Breast Cancer - Common variant of CASP8 gene associated with reduced risk of breast cancer

Breast Cancer - Identification of second breast cancer gene announced

Breast Cancer - Truck driver occupation linked to increased BRCA1/2 male breast cancer mutation

Business Update - ComGenex transfers to Echelon jointly developed IP for cancer compounds

Cancer Genetics - SLIT2 and SLIT3 genes frequently methylated in gliomas and colorectal cancers

Cardiac Care - Cleveland Clinic gets $17.2 million grant to study heart attacks

Clinical Trials - Suicide gene therapy prolongs the survival of patients with malignant glioma

Cloning - Dolly the Sheep scientist gets cloning license in Britain

Colon Cancer Risk - ALOX and COX polymorphisms influence colon cancer risk in Caucasians

Cytomegalovirus - Treatment for AIDS-related cytomegalovirus receives positive recommendations

Diabetes Therapy - Hepatic insulin gene therapy may treat type 1 diabetes

Drug Delivery - Polymeric microparticles offer controlled release of hyaluronan oligomers

Drug Delivery - Polyplexes strengthen the performance of transferred DNA

Drug Development - Three-year agreement with GSK supports drug discovery and development efforts

Finance - DNA-focused molecular diagnostics company closes $2.9 million financing

Finance - Drug developer announces acceleration of employee stock option vesting

Gastroenterology - Reports advance knowledge in gastroenterology research

Gene Delivery - Synthetic vectors usher genes to cell targets

Genetic Disorders - Angiogenic protein stimulates skeletal muscle regeneration

Healthcare Coverage - Changes in reimbursement structure to aid greater adoption of brachytherapy

Heart Failure - Acquisition costs of nesiritide are offset by reduced hospital admission rate

Heathcare Coverage - PET equipment maker comments on Medicare and Medcaid coverage for PET

Hematology - Oncoretroviral-mediated factor VIII gene therapy corrects hemophilia

Hematopoiesis - MII-dependent Hox program drives hematopoietic progenitor expansion

Hepatitis C Therapy - PEGASYS combination therapy approved for hepatitis C/HIV coinfection in Europe

Hepatoblastoma - Conductin is a direct target gene of WNT signaling hepatoblastomas

Hypertension - Angiotensin II type 2 receptor protects the hearts of hypertensive mice

Immunotherapy - Co-injected DNA constructs boost the immune system's response to antigens

Legal Issues - Ruling that embryo is a person could have chilling effect