Allergy and Immunology
Interleukin-10 gene transfer battles harmful Th1-type responses
Published in Gene Therapy Weekly, March 3rd, 2005
"Recombinant adenoviruses (rAd) are efficient tools for genetic modification of human dendritic cells (DC) in vitro. Infection of DCs by rAd encoding beta-galactosidase (betagal) results in partial maturation of DCs, as witnessed by the upregulation of major histocompatibility complex and costimulatory molecules. Accordingly, these DCs are more potent stimulators of Th1-type proliferative responses," researchers in Netherlands report.
"We now demonstrate that infection of immature DCs with rAd encoding human interleukin (IL)-10 results in the secretion by the DCs of large amounts of...
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Source: Gene Therapy Weekly (2005-03-03)
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