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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . March 10th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Allergy and Immunology - Interleukin-10 gene therapy protects islet grafts after transplantation

Cancer Therapy - BCL-2 inhibition sensitizes malignant cells to cancer immunotherapy

Leukemia - A cargo peptide transporter system halts aggressive leukemia and lymphoma

Oncology - Antisense molecules targeting alpha folate receptor hinder breast cancer cells

Virology - Retroviruses transduce embryonic stem cell-derived hematopoietic progenitors

Acute Lymphoblastic Leukemia - Role of DNA microarrays in ALL diagnosis and treatment reviewed

Adenoviral Vectors - Adenoviral vectors used, CFTR expression and properties clarified

Bacteriology - Expression of plasminogen activator achieved by inducing stress responses

Biomedical Engineering - Nanobiohybrids implement fluorescent protein transfection

Business & Finance - Antibiotics-focused biopharmaceutical company announces corporate restructuring

Business & Finance - Cytoskeleton-focused company reports $2.2M Q4 revenues, provides oncology update

Business & Finance - TF decoy-technology company reports improved revenues, lower losses in 2004

Business Update - Clinical testing lab announces entry into the flow cytometry resting market

Business Update - ExonHit launches SpliceArray Service with GPCR and ion channel microarrays

Business Update - German biotech company transfers lab automation business to AVISO GmbH

Business Update - Glaxo makes $1.0 million payment, starts phase 2 studies of oral platelet drug

Cancer Therapy - 'T-body' approach may have therapeutic potential in disseminated prostate cancer

Cancer Therapy - Genomics companies partner to investigate role of cancer genes

Cancer Therapy - Particle therapy technology to treat tumors to be installed at Heidelberg center

Cancer Therapy - Resveratrol displayed chemopreventive effects

Cardiology - Simvastatin boosts the efficacy of proangiogenic gene therapy

Chronic Liver Disease - Metallothionein gene therapy reverses liver fibrosis in mice

Clinical Trials - Results of phase 2 clinical trials with recombinant human thrombin announced

Cloning - pTOC-T vector constructed by using GST-ParE toxin for direct cloning

Dermatology - Adenovirus-based gene transfer prevents cancer in xeroderma pigmentosum models

Drug Delivery - Introns are required for prolonged apolipoprotein A-I transfection

Drug Delivery - Non-viral vectors make efficient antisense oligonucleotide delivery systems

Drug Development - Intrapleural gene therapy may cure human alpha1-antitrypsin deficiency

Drug Development - Phenylalanine aminomutase analyzed and cloned

Drug Resistance -  C. albicans transcription factor Upc2p regulated drug resistance

Embryogenesis - Mitochondrial SDHD gene required for early embryogenesis

Finance - Biopharmaceutical company reports 4Q, year-end 2004 financial results

Finance - Biotechnology company reports fiscal 2005 second quarter results

Finance - Genetic testing company closes $9.3 million private placement of common shares

Finance - Research organization posts record 2004 revenues

Fungal Infection - Phase 3 trial results evaluating anidulafungin for fungal infection announced

Gastroenterology - Studies advance knowledge in gastroenterology research

Gene Research - Public-private support enables expanded contribution to genotyping project

Genomics and Genetics - Mendocino county, California, mulls organic pot certification

Genomics and Genetics - Researchers: Therapeutic cloning ban could hurt economy

Hematology - Fetal stem cells are advantageous for developing ex vivo gene therapy

Hematology - Researchers provide details of new studies and findings in the area of hematology

Hepatitis B Vaccine - European approval announced for Fendrix, GSK's hepatitis B vaccine

Hereditary Angioedema - Companies sign manufacturing agreement for recombinant human C1 inhibitor

Human Cloning - Proposed amendment would ban human cloning in Arizona

Huntington Disease - Intrabodies confront dysfunctional protein activity

Immunology - Researchers' work adds to immunology body of knowledge

Immunotherapy - Interleukins and gene corrected bone marrow cells remedy immunodeficiency

Legal Issues - Judge rules Texas infant can be taken off life support

Liver Cancer - Nobiletin inhibits hepatocarcinoma cell proliferation in vitro

Malignant Melanoma - Viragen files to expand cancer approval for Multiferon in Sweden

Melanoma - Firefly protein illuminates virus' hunt of metastasized melanoma cells

Metastatic Melanoma - Special protocol assessment for trial of metastatic melanoma treatment completed

Neural Stem Cell Research - Oct-3/4 repression accelerates differentiation of neural progenitor cells

Oncology - Pro-apoptotic gene therapy destroys prostate cancer

Oncology - Recent findings illuminate research in oncology

Oncology - Systems biology-tech firm gets U.S. NCI grant for analysis of cancer networks

Osteoporosis - Pharma company adds time to prepare new drug application for osteoporosis drug

Ovarian Cancer - Researchers evaluating new therapy for advanced ovarian cancer

Personnel - Biopharmaceutical company adds two virologists to its scientific resource board

Personnel - Protein-focused biotech company names Dartmouth cancer researcher to board

Promyelocytic Leukemia - Dominant molecular signatures of PML influenced by independent events

Protein Expression - Targeted in vivo expression of proteins in the calyx of Held reported

Pulmonary Medicine - Survivin and p53 modulate the influence of quercetin on lung cancer cells

Respiratory Medicine - Ultrasonic nebulization supports polyplex stability during aerosolization

Spinal Cord Injury - Addition of gene to stem cell therapy prevents pain syndrome

Stem Cell Research - IREM-1 is an inhibitory receptor expressed by myeloid cells

Stem Cells Research - Stem cells may be target cells in development of cancer

Streptococcus - Antimicrobial gene prevents skin infection

Stroke - Confirmatory study of desmoteplase begins

Transplant Medicine - Alabama boy woos Capitol Hill in marrow transplant campaign

Transplant Medicine - Woman donates kidney to coworker

Vaccine Development - The adjuvant CPG 7909 may allow two-dose hepatitis B vaccine regimens

Vaccines Development - New findings in the area of vaccines development described

Vector Development - Low-pressure chromatography synthesizes PEG-peptides for gene delivery

Virology - Oncolytic adenovirus selects hypoxic tumor cells for destruction

Virology - Recombinant adenoviruses initiate complement activation

Virology - Recombinant baculovirus vectors could transport genes to the nervous system

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