Gastroenterology
TRAIL gene transfer keeps pancreatic tumors from growing in murine livers
Published in Gene Therapy Weekly, March 24th, 2005
"Local and locoregional administration of adenovectors expressing the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene has been demonstrated to be useful in treating established tumors in animals. Moreover, expression of the TRAIL gene from the human telomerase reverse transcriptase (hTERT) promoter can be used to prevent possible liver toxicity of the TRAIL gene," researchers in the United States report.
"However, it remains unknown whether systemic administration of the TRAIL-expressing adenovector can be used for cancer therapy," according to D. Jacob...
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Source: Gene Therapy Weekly (2005-03-24)
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