Endometriosis

Enhanced gene expression may confer resistance to cytokine-induced apoptosis

Published in Gene Therapy Weekly, March 24th, 2005

Enhanced production of antiapoptotic proteins may induce resistance to cytokine-induced apoptosis in endometrial cells, suggests a study from Japan.

"In order to evaluate the involvement of cell proliferation and apoptosis in the pathogenesis of endometriosis, we investigated the effects of interferon-gamma (IFN-gamma) on cell growth inhibition and apoptosis of cultured ovarian endometriotic cyst stromal cells (ECSC), eutopic endometrial stromal cells with endometriosis (ESCwE), and normal endometrial stromal cells (NESC) by modified methylthiazoletetrazolium assay, 5-bromo-2'-deoxyuridine incorporation assay and internucleosomal DNA fragmentation assay.

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Source: Gene Therapy Weekly (2005-03-24)

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