Oncology
Gene silencing sensitizes prostate cancer to cancer therapy
Published in Gene Therapy Weekly, March 24th, 2005
According to recent research published in the journal Cancer Gene Therapy, "the type 1 insulin-like growth factor receptor (IGF1R) is overexpressed in prostate cancer, and mediates proliferation, motility, and survival. Many prostate cancers harbor inactivating PTEN mutations, enhancing Akt phosphorylation. This activates the principal antiapoptotic pathway downstream of the IGF1R, calling into question the value of IGF1R targeting in this tumor."
"The aim of the current study was to assess the effect of IGF1R gene silencing in prostate cancer cells that lack functional PTEN protein....
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2005-03-24)
More Articles from Gene Therapy Weekly
- Allergy and Immunology
Small molecule inhibitors suppress nanoparticle-mediated inflammatory response - Gastroenterology
TRAIL gene transfer keeps pancreatic tumors from growing in murine livers - Obstetrics
Adenoviral vectors deliver genes to fetal murine muscle in utero - Oncology
CXCR4 knockdown slows breast tumor growth and invasion - Acute Intracerebral Hemorrhage
Journal publishes results of acute intracerebral hemorrhage study - Addiction Medicine
Cocaine hydrolase gene delivery blunts the heart's response to cocaine - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
