Renal Disease
Kidney surface gene transfer features selective transgene expression
Published in Gene Therapy Weekly, March 24th, 2005
"We developed a gene transfer following the administration of naked plasmid DNA (pDNA) to the kidney surface in mice, and found that the luciferase levels produced in the applied kidney were significantly higher than those produced in another kidney," researchers in Japan report.
"In contrast, stable renal gene expression was not observed in the case of intraperitoneal or intravenous administration of pDNA. The level of gene expression after instillation of pDNA to the kidney surface reached maximum at 12 hours and gradually diminished thereafter," wrote R. Hirayama and colleagues,...
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Source: Gene Therapy Weekly (2005-03-24)
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