Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . March 31st, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Diabetes Therapy - Antigen-specific transduced T cells reverse type 1 diabetes in mice
Gastroenterology - Gene therapy enables radioiodine therapy to target colon cancer
Oncology - Modified bacteria wreak havoc with cancer cells
Virology - Immunogenic peptides in retroviral vectors may confound gene therapy
Virology - Recombinant adenoviral vectors alter major drug metabolizing enzymes
Allergy & Immunology - Interferon-gamma helps myeloid dendritic cells respond to CpG DNA
Angina - Company launches phase IIb trial in patients with severe coronary artery disease
Angina - Severe angina patients show prolonged clinical benefit from gene therapy
Angiology - RGD-modified liposomes guide therapy to vascular targets
Anthrax - Researchers describe findings in anthrax studies
Atherosclerosis - Reports describe recent advances in atherosclerosis research
Oncology - Findings in oncology provide new insights
Bacteriology - New findings in the area of bacteriology described
Basal Cell Cancer - PTCH polymorphism mediates susceptibility to basal cell carcinoma
Biomedical Engineering - Crosslinked hyaluronan film delivers DNA vector to tissues
Biomedical Engineering - Phenylalanine-modified dendrimers have high transfection capabilities
Bladder Cancer - Relative copy number of bladder cancer genes determined by real-time PCR
Breast Cancer - Breast cancer resistance protein gene expression modulated using siRNAs
Breast Cancer - ERCC2 genotypes and corresponding haplotype linked with breast cancer risk
Breast Cancer - HER-2/neu overexpression decreases wild-type p53 via activating PI3K pathway
Breast Cancer - XPD polymorphism increases breast cancer risk from PAH-DNA adducts/cigarettes
Business & Finance - ATryn maker reports "significant progress" in 2004
Cancer Immunotherapy - Lymphocyte contamination makes genetically altered dendritic cells disappear
Cancer Therapy - Research add new data to cancer therapy body of knowledge
Cancer Therapy - Telomerase promoter enhances the efficacy of lung cancer suicide gene therapy
Cell Biology - Immortalized cells foster the study of liver diseases
Collaborations - Companies enter collaboration to develop therapeutic hepatitis B vaccine
Collaborations - Red Cross affirms continued support of joint projects with drug research company
Colorectal Cancer - MTHFR 677 TT and MTR 2756 GG genotypes confer reduced colorectal cancer risk
DNA Damage - TDP1 overexpression counteracts DNA damage mediated by topoisomerases I and II
Dermatology - New findings in the area of dermatology detailed
Disease Associations - Epigenetic regulation of gene expression studied, critical roles established
Drug Delivery - HepDirect prodrugs guide therapy to liver cells
Drug Development - CD33 expression influences gemtuzumab ozogamicin-based toxicity
Drug Discovery - Scientists solve 3-D structures of PCNA complexes
Endocrinology - New research in the area of endocrinology detailed
Endocrinology - XIAP gene transfer corrects the adverse effects of immunosuppressive therapy
Finance - Cancer-focused biopharmaceutical company reports Q4, year end financial results
Finance - Genetics-focused biopharmaceutical company announces full-year 2004 results
Finance - Imaging systems maker reports 4th quarter and full year 2004 financial results
Financing - Research organization receives grant to research cancer cell lines
Gene Delivery - Biomaterial-based gene delivery multiplies bioengineering possibilities
Gene Delivery - Chitosan chain length governs the efficacy of polyplex-based gene transfer
Gene Research - Keck Foundation awards $1.25 million to genetics and genomics laboratory
Gene Research - Survey of gene researchers suggests IT vendors capable of tackling technology
Gene Research - Targeting Hedgehog signaling pathway with small molecules is collaborative work
Gene Silencing - Electrically mediated short interfering RNA delivery transduces murine muscles
Gene Transfer - pDNA loaded calcium phosphate nanoparticles have high transfection efficiencies
Genomics - GE Healthcare named international distributor of genome research products
Genotoxicity - Genotoxicity of ambient outdoor air due to hundreds of identified compounds
HIV/AIDS Research - Phase 1 trial results for HIV treatment announced
HIV/AIDS Testing - Utility of virologic assays in HIV management discussed iat conference
HIV/AIDS Therapy - BioScience company announces data from HIV treatment program
HIV/AIDS Therapy - Two chemicals boost immune cells' ability to fight HIV without gene therapy
Head & Neck Cancer - Antisense oligonucleotides stop osteopontin activity in oral cancer cells
Helicobacter Pylori - H. pylori polymorphism differs between African and Caucasian Americans
Hemophilia B - Major genes share the control of factor IX antibody expression
Hepatitis B Therapy - Short hairpin RNA clears hepatitis B virus from murine livers
Hepatitis C Virus - U.S. FDA approves Pegasys and Copegus as hepatitis C treatment for HIV patients
Hypertension - Researchers publish new studies and findings in the area of hypertension
Infections - Expression of Shigells secretion system studied, involvement of sensor detailed
Inflammation - Leptomycin B studied, suppression of metalloproteinase and inflammation shown
Kidney Disease - Company issued U.S. patent covering methods for treating chronic kidney disease
Leukemia - Gamida-Cell, Teva to develop and commercialize StemEx for leukemia
Lysosomal Storage Disorders - Gene therapy reverses nervous system damage in animal model
Muscular Dystrophy - Delivery method may represent best muscle gene therapy
Myocardial Infarction - VEGF165 and angiopoietin-1 protect the ischemic heart
Neuroscience - Research in neuroscience provides new insights
Obesity - Therapeutic targets for obesity-associated diabetes based on inflammation link
Oncogenes - MYCN directly modulated baseline MDM2 levels in neuroblastoma pathogenesis
Oncology - Adenovirus-mediated caspase-8 gene transfer sensitizes cancer to TRAIL
Oncology - Data advance knowledge in oncology research
Oncology - Enzyme inhibitors augment sulindac sulfide in colon cancer cells
Oncology - Melanoma cells require interleukin-18 to produce stem cell factor
Oncology - Promoter-driven apoptin expression impedes small-cell lung cancer growth
Oncology - Tamoxifen-resistant breast cancer cells harbor distinct genetic changes
Oral Health - Number of women dentists, practioners of oral, maxillofacial surgery increasing
Osteoarthritis - Combination gene therapy heals cartilage
Pain Medicine - N-methyl-D-aspartate receptor regulates morphine tolerance and nociception
Personnel - Eric Dobmeier named VP of corporate development by genetics-focused company
Prostate Cancer - Epigenetic changes in prostate cancer reviewed
Proteomics - New findings in the area of proteomics detailed
Pulmonary Medicine - Electroporation enables therapeutic genes to clear lung fluid
Restenosis - Perivascular gene transfer staunches angioplasty-induced neointima formation
Severe Combined Immunodeficiency - Panel recommends some gene therapy limits
Stem Cell Research - Embryonic cells retain pluripotent potential after Sendai virus transfection
Stomach Cancer - Allelic distribution of STRs correlates with different gastrointestinal tumors
Stroke - Journal publishes results of acute intracerebral hemorrhage trial
Thromboembolic Disease - Bitistatin studied, potential relevance in thromboembolic disease indicated
Thyroid Cancer - Company gets European marketing approval of Thyrogen for thyroid tissue ablation
Transplant Medicine - Bone marrow transplant fails for 8-year-old girl
Transplant Medicine - Illinois man donates kidney to sister-in-law
Vector Development - A number of factors sway the success of adenovirus-mediated transduction
Vector Development - Headgroup interactions determine the extent of liposome-based transfection
Vector Development - PEI-based core-shell nanoparticles may be good gene carriers
Vector Development - Polymeric conjugates conduct in vitro gene delivery
Vector Development - Recombinant Newcastle disease virus transfers genes to tumor cells
Virology - Baculovirus transduction offers a viable alternative to plasmid transfection
Virology - The adenovirus type 5 fiber uses a unique cell entry pathway for gene transfer
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