Published in Gene Therapy Weekly, March 31st, 2005
According to recent research from the United States, "recombinant adenovirus (Ad) serotype 5 is a vector commonly used for gene delivery. Although this vector has a natural tropism for the liver, there is a limited understanding of how Ad administration affects one of the primary hepatic processes, drug metabolism. The effects of systemic administration of a model recombinant adenoviral vector on two hepatic cytochrome P450 (P450) enzymes, CYP3A2 and 2C11, were investigated."
"Sprague-Dawley rats were treated with one of six vector doses, ranging from 5.7 x 106 to 5.7 x...
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