Virology

Recombinant adenoviral vectors alter major drug metabolizing enzymes

Published in Gene Therapy Weekly, March 31st, 2005

Recombinant adenoviral vectors alter major drug metabolizing enzymes.

According to recent research from the United States, "recombinant adenovirus (Ad) serotype 5 is a vector commonly used for gene delivery. Although this vector has a natural tropism for the liver, there is a limited understanding of how Ad administration affects one of the primary hepatic processes, drug metabolism. The effects of systemic administration of a model recombinant adenoviral vector on two hepatic cytochrome P450 (P450) enzymes, CYP3A2 and 2C11, were investigated."

"Sprague-Dawley rats were treated with one of six vector doses, ranging from 5.7 x 10⁶ to 5.7 x...

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Source: Gene Therapy Weekly (2005-03-31)

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