Oncogenes

MYCN directly modulated baseline MDM2 levels in neuroblastoma pathogenesis

Published in Gene Therapy Weekly, March 31st, 2005

MYCN directly modulated baseline MDM2 levels as part of the mechanism for neuroblastoma pathogenesis.

"The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC oncogenes activate both proliferative and apoptotic cellular pathways and, accordingly, inhibition of p53-mediated apoptosis is a prerequisite for MYC-driven tumorigenesis," scientists in the United States reported.

"To identify novel transcriptional targets mediating the MYCN-dependent phenotype, we screened a MYCN-amplified neuroblastoma cell line by using chromatin...

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Source: Gene Therapy Weekly (2005-03-31)

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