RGD-modified liposomes guide therapy to vascular targets

"Local drug delivery has become an important treatment modality for the prevention of thrombotic events following coronary angioplasty. In this study, we investigate the ability of liposomes bearing surface conjugated linear Arg-Gly-Asp (RGD) peptide (GSSSGRGDSPA) moieties to target and bind activated platelets, and the effect of such RGD-modified liposomes on platelet activation and aggregation," scientists in the United States report.

"The binding of RGD-liposomes to human platelets-was assessed by fluorescence microscopy, phase contrast microscopy and flow cytometry," wrote A. Sengupta and...

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