Pain Management

Article describes gene therapy strategy for inflammation-associated chronic pain

Published in Gene Therapy Weekly, April 14th, 2005

More effective treatments for chronic pain associated with inflammation, such as the pain caused by arthritis, inflammatory bowel disorders, burns, neuropathy, and some types of cancer, could take the form of gene therapy to block changes in sensory nerve cells that over-stimulate peripheral nerve endings, causing pain, according to a recent article.

A study using a modified form of the herpes simplex virus to introduce an antisense gene into sensory neurons in the hindpaws of mice demonstrated that the antisense DNA blocked the normal response to an inflammatory stimulus and prevented the development of hyperalgesia, or excessive sensitivity and pain.

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Source: Gene Therapy Weekly (2005-04-14)

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