Virology
Modified adenoviruses may not yield anticipated results in in vivo research
Published in Gene Therapy Weekly, April 14th, 2005
"Expression of antigens in dendritic cells (DC) can stimulate protective immunity against both viral infection and tumor growth, making them important targets for gene therapy. In-vitro-generated DC are commonly used in gene delivery studies with the assumption that the results will correlate with in vivo activity. Adenovirus Type 5 (Ad5) vectors have been widely used with DC, but these cells lack the primary receptor (CAR) used by Ad5 and are poorly infected," scientists in the United States report.
"We investigated the use of Ad5 vector particles pseudotyped with fibers...
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Source: Gene Therapy Weekly (2005-04-14)
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