Diabetes Therapy
Beta-cells that secrete GLP-1 have improved glucose-responsiveness
Published in Gene Therapy Weekly, April 14th, 2005
According to published research from Sweden, "type 2 diabetes is a polygenic disorder characterized by increased insulin resistance, and impaired insulin secretion leading to abnormalities of glucose and lipid metabolism. Reduced responsiveness of the beta-cells to glucose is a critical feature of this syndrome. Glucagon-like peptide 1, a product of the pro-glucagon gene makes beta-cells competent and has many other anti-diabetic properties."
"We speculated whether GLP-1-based gene therapy could be an approach for treatment of type 2 diabetes. We started with a clone of rat...
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Source: Gene Therapy Weekly (2005-04-14)
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