Oncology
Melanoma differentiation-associated-7 gene transfer eradicates prostate cancer
Published in Gene Therapy Weekly, April 14th, 2005
"We have previously reported that overexpression of the melanoma differentiation-associated gene-7 (mda-7) using a replication-defective adenovirus (Ad-mda7), results in tumor-specific growth suppression and induction of apoptosis in wide variety of cancer cells. In the present study, we investigated the antitumor activity of Ad-mda7 and the underlying mechanism in human prostate cancer cells and normal prostate epithelial cells," scientists in the United States report.
"Overexpression of MDA-7 induced significant (p=0.001) suppression of cell growth and apoptosis in...
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Source: Gene Therapy Weekly (2005-04-14)
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