Adult T-Cell Leukemia

TSLC1 overexpression may be a molecular marker for acute-type ATL

Published in Gene Therapy Weekly, April 14th, 2005

Overexpression of tumor suppressor in lung cancer 1 may be a molecular marker for acute-type ATL.

According to a study from Japan, "Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1) infection occurs in 2 to 4% of the HTLV-1 carriers with a long latent period, suggesting that additional alterations participate in the development of ATL.

"To characterize and identify novel markers of ATL, we examined the expression profiles of more than 12,000 genes in 8 cases of acute-type ATL using microarray."

"One hundred ninety-two genes containing interleukin 2 (IL-2) receptor alpha were up-regulated more than...

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Source: Gene Therapy Weekly (2005-04-14)

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