Leukemia

TP53 deletions related to higher tendency for myeloma cells to become leukemic

Published in Gene Therapy Weekly, April 14th, 2005

Frequent TP53 deletions might relate to a heightened tendency for myeloma cells to become leukemic.

According to recent research published in the journal Cancer Genetics and Cytogenetics, "A combination of cytoplasmic immunofluorescence to detect the immunoglobulin light chain and an interphase fluorescence in situ hybridization technique was used to study the recurrent genetic abnormalities in 14 patients with plasma cell leukemia (PCL). Of the 14 patients studied, 5 had primary and 9 secondary PCL. Chromosomal abnormalities were detected in all 14 patients (100%)."

"Deletions of 13q14 were detected in 11 (78%) cases and deletions of 17p13.1...

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Source: Gene Therapy Weekly (2005-04-14)

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