Oncology
DNA-PK inhibition is a viable strategy for enhancing ionizing radiation
Published in Gene Therapy Weekly, April 14th, 2005
"Double-strand breaks (DSBs) arise endogenously during normal cellular processes and exogenously by genotoxic agents such as ionizing radiation (IR). DSBs are one of the most severe types of DNA damage, which if left unrepaired are lethal to the cell. Several different DNA repair pathways combat DSBs, with nonhomologous end-joining(NHEJ) being one of the most important in mammalian cells," researchers in England report.
"Competent NHEJ catalyzes repair of DSBs by joining together and ligating two free DNA ends of little homology (microhomology) or DNA ends of no homology. The...
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Source: Gene Therapy Weekly (2005-04-14)
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