Virology
Caffeine keeps retroviruses from transducing nondividing cells
Published in Gene Therapy Weekly, April 21st, 2005
"Caffeine is an efficient inhibitor of DNA repair and DNA damage-activated checkpoints. We have shown recently that caffeine inhibits retroviral transduction of dividing cells, most likely by blocking postintegration repair. This effect may be mediated at least in part by a cellular target of caffeine, the ataxia telangiectasia-mutated and Rad3-related (ATR) kinase," researchers in the United States report.
"In this study, we present evidence that caffeine also inhibits efficient transduction of nondividing cells. We observed reduced transduction in caffeine-treated growth-arrested cells...
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Source: Gene Therapy Weekly (2005-04-21)
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