Published in Gene Therapy Weekly, April 21st, 2005
According to published research from the United States, "elevated serum tumor necrosis factor alpha (TNF-alpha) levels predict mortality in patients with alcoholic liver disease. Administration of anti-TNF-alpha antibodies, obliteration of Kupffer cells or gut sterilization protect against ethanol-induced hepatocellular injury in animal models. In this study, we evaluated the in vivo efficacy of an antisense phosphorothioate oligodeoxynucleotide (S-ODN) targeted against TNF-alpha mRNA (TJU-2755)."
"Naive rats that were administered TJU-2755 (10 mg/(kg body weight (BW)/day) for 2...
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