Addiction Medicine
Tumor necrosis factor antisense therapy fights alcoholic liver disease
Published in Gene Therapy Weekly, April 21st, 2005
According to published research from the United States, "elevated serum tumor necrosis factor alpha (TNF-alpha) levels predict mortality in patients with alcoholic liver disease. Administration of anti-TNF-alpha antibodies, obliteration of Kupffer cells or gut sterilization protect against ethanol-induced hepatocellular injury in animal models. In this study, we evaluated the in vivo efficacy of an antisense phosphorothioate oligodeoxynucleotide (S-ODN) targeted against TNF-alpha mRNA (TJU-2755)."
"Naive rats that were administered TJU-2755 (10 mg/(kg body weight (BW)/day) for 2...
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Source: Gene Therapy Weekly (2005-04-21)
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