Vector Development
Intact microtubules are a barrier to baculovirus transfection
Published in Gene Therapy Weekly, April 28th, 2005
"Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), a potent virus for mammalian cell gene delivery, possesses an ability to transduce mammalian cells without viral replication. We examined the role of the cellular cytoskeleton in the cytoplasmic trafficking of viral particles toward the nucleus in human hepatic cells," researchers in Finland report.
"Microscopic studies showed that capsids were found in the nucleus after either viral inoculation or cytoplasmic microinjection of nucleocapsids. The presence of microtubule (MT) depolymerizing agents caused the amount...
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Source: Gene Therapy Weekly (2005-04-28)
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