Colorectal Cancer
Promoter methylation downregulates CDX2 expression in colorectal carcinomas
Published in Gene Therapy Weekly, April 28th, 2005
"CDX2 (caudal type homeobox transcription factor 2) is a homeobox protein, which is expressed in intestinal epithelium. CDX2 has been considered to play a role as a tumor suppressor gene in colorectal cancer because its expression is lacking in colorectal carcinomas, but preserved in adenomas.
"The point mutations have been found to account for loss of CDX2 expression, but the main mechanism responsible for CDX2 gene inactivation is less understood," investigators in Japan report.
"We analyzed methylation and expression status of CDX2 in colorectal cancer...
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Source: Gene Therapy Weekly (2005-04-28)
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