Oncology
Silenced insulin-like growth factor binding protein-5 restricts neuroblastoma
Published in Gene Therapy Weekly, April 28th, 2005
According to recent research published in the journal Cell Death and Differentiation, "signal transduction through the insulin-like growth factor (IGF) axis is implicated in proliferation, differentiation and survival during development and adult life. The IGF axis includes the IGF binding proteins (IGFBPs) that bind IGFs with high affinity and modulate their activity. In neuroblastoma (NB), a malignant childhood tumor, we found that IGFBP-5 is frequently expressed."
"Since NB is an IGF2-sensitive tumor, we investigated the relevance and the function of endogenous...
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Source: Gene Therapy Weekly (2005-04-28)
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