Hematology
Modified natural killer cells destroy acute myeloid leukemia cells
Published in Gene Therapy Weekly, April 28th, 2005
According to scientists in Germany, "we directed the human natural killer (NK) cell line YT by gene transfer of a humanized chimeric immunoglobulin T cell receptor to CD33, a marker on myeloid leukemias. The chimeric receptor was generated using a CD33 specific single-chain Fv (scFv) fragment based on the humanized antibody HuM195, the human IgG1 Fc domains and the human CD3 zeta signal chain."
"YT cells transfected by electroporation with the chimeric receptor gene specifically lysed the acute myeloid leukemia (AML) cell line KG1," reported T. Schirrmann and colleagues, University...
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Source: Gene Therapy Weekly (2005-04-28)
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