Hepatology
Cytokine cross-talk reconstitutes liver growth following liver injury
Published in Gene Therapy Weekly, April 28th, 2005
According to recent research published in the journal Hepatology, "prostaglandins are hepatoprotective molecules generated in liver regeneration by the rapid induction of cyclooxygenase-2 (COX-2). Cardiotrophin-1 (CT-1) and vascular endothelial growth factor (VEGF) are other hepatoprotective mediators upregulated at 24 hours after partial hepatectomy. The interactions among these molecules during liver regeneration have not yet been defined."
"Here we show that rats subjected to partial hepatectomy treated with NS-398, a specific COX-2 inhibitor, exhibited cell cycle...
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Source: Gene Therapy Weekly (2005-04-28)
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