Published in Gene Therapy Weekly, April 28th, 2005
According to a study from South Korea, "hypoxia-inducible factor-1 (HIF-1) is one of the key mammalian transcription factors and shows increased levels in both protein stability and intrinsic transcriptional activity during low oxygen tension."
"Hypoxia-activated functional HIF-1 protein binds to hypoxia-responsive elements (HRE) in the enhancers of several genes including vascular endothelial growth factor (VEGF), the major player in angiogenesis, and...
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