Oncology
Demethylating agents augment antitumor immunotherapy
Published in Gene Therapy Weekly, April 28th, 2005
"We have reported that i.d. injection of plasmids encoding hsp70 and a suicide gene transcriptionally targeted to melanocytes generates specific proinflammatory killing of melanocytes. The resulting CD8+ T-cell response eradicates systemically established B16 tumors," scientists in the United States report.
"Here, we studied the consequences of that CD8+ T-cell response on the phenotype of preexisting tumor. In suboptimal protocols, the T-cell response selected B16 variants, which grow extremely aggressively, are amelanotic and have lost expression of the tyrosinase and tyrosinase-related protein...
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Source: Gene Therapy Weekly (2005-04-28)
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