Pulmonary Medicine
A supercritical carbon dioxide process stabilizes DNA-chitosan constructs
Published in Gene Therapy Weekly, April 28th, 2005
"The present study examined the stability of a gene in powders prepared with supercritical carbon dioxide (CO2 ) from the viewpoints of the ternary structure of DNA and in vivo transfection potential. An aqueous chitosan-pCMV-Luc complex solution containing mannitol was injected into the stream of a supercritical CO2 /ethanol admixture to precipitate a gene powder. The obtained gene powders and gene solutions were placed in stability chambers at 25 or 40 degrees C for 4 weeks," investigators in Japan report.
"The integrity and transfection potency of the...
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Source: Gene Therapy Weekly (2005-04-28)
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