Gene Therapy Weekly

Cancer Immunotherapy - Interleukin 12 gene transfer retards fibrosarcoma growth and metastasis

Drug Development - ONYX-015 and MAP chemotherapy may help some patients with advanced sarcomas

Endocrinology - Limited diffusion impedes the transfection of pituitary tumors

Prostate Cancer - Radiotherapy and sKDR gene delivery demolish malignant prostate tumors

Virology - Pseudotyped lentiviral vector steers therapy to metastatic melanoma

Adverse Drug Reaction - Pre-existing immunity alters host response to systemic adenoviral vector

Allergy & Immunology - Inhaled antisense oligonucleotide alleviates murine asthma

Androgen Receptor - Notch signaling mediator Hey1 is an androgen receptor corepressor

Angina - Phase IIb GENASIS clinical trial receives recommendation to proceed

Angiology - Alternate techniques increase the depth of saphenous vein gene transfer

Antisense Technology - Morpholino antisense oligomers targeting human midkine fights cancer

Oncology - Studies add new findings to oncology body of knowledge

Apoptosis - E1A activated transcription of p73 and Noxa to induce apoptosis

Apoptosis - p53 has crucial role in signal transduction pathways of silica-induced apoptosis

Atherosclerosis - Effects of silencing leukocyte-type 12/15-lipoxygenase reported

Biological Therapy - Transfected B cells defeat problems linked to dendritic cell-related therapy

Biomedical Engineering - Scaffolds containing PEI-condensed DNA regenerate bone growth

Breast Cancer - Ki67 breast cancer marker correlates with regulation of apoptosis-related genes

Virology - Researchers report details of new studies and findings in the area of virology

Breast Cancer - PEA3 and AP-1 involved in regulation of breast cancer-linked gene, mammaglobin

Breast Cancer - Real-time PCR measures Epstein-Barr virus DNA in archival breast adenocarcinomas

Business Update - Dr. James W. Ryan, IP company, collaborate to commercialize key genomic patents

Business Update - Genetronics announces name change

Business Update - Pharmaceutical firm discontinues AAV gene therapy funding

Cancer Genetics & Genomics - Single-round PCR assay detects BCL2-IGH

Cancer Immunotherapy - Tumor cell genes encode ligands recognized by CD4 regulatory T cells

Cancer Inhibitor - Leukemia inhibitory factor receptor characterized in goldfish

Cancer Prevention - Anthocyanidins from fruits and vegetables inhibit tumor cell growth

Cardiology - Periadventitial angiopoietin-1 gene transfer generates neovascular growth

Cervical Cancer - p27(Kip1) downregulated telomerase activity in human cervical cancer

Chromatin - Chromatin-polycomb protein association examined, physiology clarified

Colon Cancer - Curcumin inhibits colon cancer via PPARgamma activation

Colon Cancer - Gastrin promotes colon cancer via CCK-2 receptor-mediated COX-2 induction

Colon Cancer - Quercetin inhibits beta-catenin/Tcf signaling in colon cancer cells

Colorectal Cancer - n596 gene deletion causes hereditary nonpolyposis colorectal cancer

Diabetes Therapy - Chimeric rice seeds stimulate beta-cell insulin secretion

Diabetes Therapy - Transcription factors increase insulin production in diabetic mice

Diet & Nutrition - Epithilial cell biotin uptake studied, cellular and molecular aspects defined

Drug Delivery - Large-scale production techniques extend lipoplex shelf-life

Drug Development - Glycerophosphoinositols inhibit tumor cells from invading extracellular matrix

Endocrinology - Reports add new data to endocrinology research