Atherosclerosis

Effects of silencing leukocyte-type 12/15-lipoxygenase reported

Published in Gene Therapy Weekly, May 5th, 2005

Recent research from the United States has documented the effects of silencing leukocyte-type lipoxygenase using short interfering RNAs.

"The leukocyte-type 12/15-lipoxygenase (12/15-LO) has been implicated in the pathogenesis of atherosclerosis, hypertension, and diabetes. 12/15-LO and its products are associated with LDL oxidation, cellular growth, migration, adhesion, and inflammatory gene expression in monocytes/macrophages, endothelial cells, and vascular smooth muscle cells (VSMCs).

"Our objective, therefore, was to develop novel expression vectors for short interfering RNAs (siRNAs) targeting 12/15-LO to evaluate its functional relevance in...

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Source: Gene Therapy Weekly (2005-05-05)

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